other vasculitides


“Title of publication” Journal, Year

Penn investigators involved (*lead)

What we learned

“Sequence-based screening of patients with idiopathic polyarteritis nodosa, granulomatosis with polyangiitis, and microscopic polyangiitis for deleterious genetic variants in ADA2”

Arthritis & Rheumatology, 2020

Dr. Peter Merkel*

Dr. Antoine Sreih

- Deficiency of adenosine deaminase 2 is found in a subset of patients with idiopathic polyarteritis nodosa (PAN) but not in GPA or MPA

- Identification of this genetic variant may lead to alternative therapies which are not typically used in PAN

“Comparison of aortitis vs noninflammatory aortic aneurysms among patients who undergo open aortic aneurysm repair” Arthritis & Rheumatology, 2020

Dr. Rennie Rhee*

- The following risk factors are associated with aortitis identified after surgery: older age, female sex, other aortic or arterial wall thickening on imaging, and absence of a history of coronary artery disease

- Patients with these characteristics may benefit from evaluation by a rheumatologist prior to surgery